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Chu, Jun(储军), PhD, Associate Professor

   日期:2016-08-26     浏览:151    
核心提示:Jun Chu receivedhis Ph.D. degree in Biomedical Engineering from Wuhan National Laboratory for Optoelectronics at Huazhon

 

Jun Chu received his Ph.D. degree in Biomedical Engineering from Wuhan National Laboratory for Optoelectronics at Huazhong University of Science and Technology in 2009, did his postdoctoral researchin Jeanny Hardy lab at University of Massachusetts, Amherstfrom 2009 to 2010 and Michael Lin lab at Stanford University from 2010 to 2015.

He has developedseveral novel fluorescent proteins (FPs) and FP-based biosensors. 1) afar-red bimolecular fluorescence complementation system (BiFC) that works very well under cell physiological conditions, which could be used for monitoring protein-protein interaction in vivo; 2)a GFP-based caspase-3 indicator(CA-GFP) with large dynamic range, which potentially can be used for visualization of cell’s spontaneous apoptosis during embryo and neuron development; 3) a brightest far-red FP, mCardinal, providing a useful tool for optical imaging in vivo; 4)a large Stokes shift orange FP (CyOFP), which can be excited together with GFP using single wavelength, allowing simultaneous visualization of two molecular events under two photon excitation in vivo; and 5) a green FP-red FP based FRET (fluorescence resonance energy transfer) pair (Clover3-mRuby3) with large dynamic range, which is useful for detecting weak or transient biochemical responses in living cells. He has first-authored and co-authored more than 15 journal and conference articles including one Nature Methods, 2 U.S. patents and one invited book chapter. He is a member of Biophysical Society and Protein Society.

His current research interests include engineering of novel infra-red FPs for optical imaging and red-absorbing chromoproteins for photoacoustic imaging, engineering of novel large Stokes shift FPs for two photon imaging, improving existing FRET pairs and development of FRET biosensors for kinases, and development of new optogentic tools for perturbing the signaling pathway in living cells.

储军,2009年获华中科技大学生物医学工程博士,于2009~2015年在美国麻省大学阿莫思特分校和斯坦福大学进行了博士后研究。开发了具有不同光学性能的荧光蛋白和基于荧光蛋白的探针。

主要包括:1)发展了新型的可用于蛋白相互作用监测的远红色荧光互补系统;
2)发展了能够用于高灵敏监测细胞凋亡过程中caspase-3活性的新探针;
3)发展了目前最亮的可用于在体荧光成像的远红色荧光蛋白;
4)发展了能够和GFP联合可用于双光子双色成像的大stokes位移的橙色蛋白;
5)发展了具有高动态范围的FRET荧光蛋白对。
已发表或合作发表了包括Nature Methods在内的15篇期刊和会议论文,申请美国专利2项,发表国际著作章节一篇。现为美国生物物理和蛋白协会会员。

联系方式:
电话:0755-86585221
E-mail:jun.chu@siat.ac.cn
单位:中国科学院深圳先进技术研究院
 


 
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