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Advanced Cell Diagnostics

  • 品牌名称:Advanced Cell Diagnostics
  • 公司名称:动态生物网品牌雷达
  • 官方主页http://www.acdbio.com/
  • 所在地区:北京
  • 浏览次数137
  • 更新日期:2016-10-29
品牌展介绍
ACD shortens the path to personalized medicine by unlocking the power of RNA biomarkers.

Advanced Cell Diagnostics, Inc. (ACD) is a leader in the emerging field of molecular pathology, developing cell- and tissue-based diagnostic tests for personalized medicine. based in the heart of Silicon Valley, ACD was founded and managed by experienced entrepreneurs in the life science industry.

ACD’s products and services are based on its proprietary RNAscope® Technology, the first multiplex fluorescent and chromogenic in situ hybridization platform capable of detecting and quantifying RNA biomarkers in situ at single molecule sensitivity.

In addition to its ongoing efforts to develop proprietary diagnostic tests for cancer management, ACD also establishes partnerships with pharmaceutical and biotechnology companies to validate biomarkers for targeted therapeutic development. These internal and external efforts will continue to position ACD as a leader in molecular diagnostics and companion diagnostics.

The company’s technology overcomes critical hurdles in the identification and validation of biomarkers for companion diagnostics. ACD’s RNAscope® platform provides a new way of localizing and measuring RNA in situ with exceptional levels of sensitivity, specificity, and the ability to multiplex. Turnaround time for a new assay is reduced to three weeks. These advantages make the technology a powerful tool to address the issue of patient and disease heterogeneity, thus shortening the path to personalized medicine.

RNAscope®---快速检测RNA表达原位杂交的新技术

Advanced Cell Diagnostics (以下简称ACD)公司最新推出的RNAscope是一种新型 RNA原位杂交技术,基于其独特的探针设计与背景抑制技术,并且融合传统RNA原位杂交技术与FISH技术的优点,使单个RNA的转录变得可视化,是目前最精准的RNA检测技术。

RNAscope试剂盒特点:

  1. 特异性强:双“ZZ”探针
  2. 敏感度高:可区分高达90%相似度的序列
  3. 准确性高:单基因原位检测
  4. 多重检测:同时检测最多达4个基因
  5. 定量检测:专业的Spot Studio Software
  6. 极佳信噪比:背景抑制技术
  7. 样本类型:脱落细胞、血样、FFPE石蜡包埋组织切片

RNAscope技术原理:

Step 1 对石蜡组织切片或者细胞爬片进行预处理,以增加通透性;
Step 2 目的RNA与特性的双“Z”探针进行杂交,目的探针是寡聚核苷酸探针,在探针的一端有与预放大系统结合的位点;
Step 3 预放大系统与目的探针杂交,放大系统与预放大系统杂交,最后标签探针与放大系统特异性杂交,在标签探针的一端是显色或者荧光基团;
Step 4 在明场或者荧光显微镜下观察显色样品。

RNAscope应用领域:
生物标记物研究、报告基因筛选、分子病理学、干细胞分化、细胞生物学、神经生物学、肿瘤学等。

RNAscope 产品主要包括:
1)根据目的片段设计的独特的双“Z”探针;
2)预处理试剂盒;
3)反应试剂盒;
4)Wash Buffer缓冲液。

RNAscope相关产品:

 
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