Applied StemCell Inc. (ASC) is a fast growing biotechnology company headquartered in Milpitas, California. Our goal is to advance gene-editing and stem cell innovation for biomedical research and the biotechnology industry. After years of research and development, ASC is proud to offer an optimized series of tools for basic research study, drug discovery, bio-processing, bio-production and preclinical applications.
We are currently focusing on three areas: (1) cell line generation for bio-production and bioassays (2) patient-relevant cell models for personalized medicine and (3) physiologically predictive animal models of human diseases. We are striving to improve and expand our technologies and product lines to meet the increasing requirements of the biomedical community.
•Establishing disease-specific isogenic models
•Developing master cell lines for antibody/protein production
•Generating iPSCs from patients containing the corrected mutations or inserted genes for pre-clinical applications
•Generating animal models (mouse/rat models)
Using our TARGATT™ technology, a gene-of-interest can be specifically inserted at a well-characterized, transcriptionally active locus in the genome with guaranteed transgene expression. This site-specific Knock-in technology has been first established in mouse models, and we have successfully applied it to human cell lines. We are moving forward to various projects that will combine the CRISPR/Cas9 technology and TARGATT™ for highly specified transgene expression.
ASC’s therapeutic pipeline will have a strong focus on monogenic blood disorders that are characterized by high genetic penetrance. Such diseases are a strong point for the company, which specializes in the genetic engineering of stem cell lineages.
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