The ubiquitin-proteasome system (UPS) plays essential roles in mediating various cellular events including gene transcription, signal transduction, cell cycle progression and protein quality control in eukaryotic cells.
Biochemically, the UPS consists of two main procedures: protein ubiquitination and proteasome degradation. Protein ubiquitination is a posttranslational modification, which is accomplished by a cascade of enzymatic reactions requiring a ubiquitin activating E1 enzyme, a ubiquitin conjugating E2 enzyme and a ubiquitin E3 ligase.
Ubiquitin can be covalently conjugated to proteins as a monomer or a polyubiquitin chain. Usually, polyubiquitin modification targets proteins to the 26S proteasome, a 3 MDa protease complex, for degradation. Monoubiquitin and lysine 63-linked polyubiquitin modifications play nonproteolytic functions. In human cells, there are more than 1,000 proteins/enzymes involved in maintaining the normal activity of the UPS. Dysregulation of the UPS has been found to be involved in the pathophysiology of a large number of human diseases including cancer, inflammatory diseases and neurodegenerative diseases.
The Ubiquitin-Proteasome Biotechnologies (UBPBio), LLC is a privately owned company, established by several scientists and investors in 2011. UBPBio is dedicated to providing the academic and industrial communities with high quality reagents to accelerate discoveries on the UPS and related pathways. Currently, we manufacture highly purified proteasomes, E1 and E2 enzymes, Ub and Ub derivatives, proteasome inhibitors and proteasome substrates. We constantly add new products to our product line. Please visit our website often for new products and special offers.
- E1 activating enzymes
- E2 conjugating enzymes
- E3 Ubiquitin Ligases
- Ubiquitin/Sumo chains
- Ubiquitin/Ubiquitin-like proteins/Mutants
- Deubiquitinating enzymes
- Proteasome/deubiquitinase inhibitors
- Fluorescent substrates
- Ubiquitin binding proteins
- Ubiquitin / UBL Derivatives
- Protein expression/purification reagents
- DNA/Protein ladders